The co-occurrence of stress-induced posttraumatic stress disorder (PTSD) and obesity is common, particularly among military personnel but the link between these conditions is unclear. Individuals with comorbid PTSD and obesity manifest other physical and psychological problems, which significantly diminish their quality of life. Current understanding of the pathways connecting stress to PTSD and obesity is focused largely on behavioral mediators alone with little consideration of the biological regulatory mechanisms that underlie their co-occurrence. In this work, we leverage prior knowledge to (...) systematically highlight such bio-behavioral mechanisms and inform on the design of confirmatory pilot studies. We use natural language processing (NLP) to extract documented regulatory interactions involved in the metabolic response to stress and its impact on obesity and PTSD from over 8 million peer-reviewed papers. The resulting network describes the propagation of stress to PTSD and obesity through 34 metabolic mediators using 302 documented regulatory interactions supported by over 10,000 citations. Stress jointly affected both conditions through 21 distinct pathways involving only two intermediate metabolic mediators out of a total of 76 available paths through this network. Moreover, oxytocin (OXT), Neuropeptide-Y (NPY), and cortisol supported an almost direct propagation of stress to PTSD and obesity with different net effects. Although stress upregulated both NPY and cortisol, the downstream effects of both markers are reported to relieve PTSD severity but exacerbate obesity. The stress-mediated release of oxytocin, however, was found to concurrently downregulate the severity of both conditions. These findings highlight how a network-informed approach that leverages prior knowledge might be used effectively in identifying key mediators like OXT though experimental verification of signal transmission dynamics through each path will be needed to determine the actual likelihood and extent of each marker’s participation. (shrink)

It is well known that when resolution occurs in the stichic iambics and trochaics of tragedy word-end is not found between the two shorts so produced: w or, more accurately, that the first short of resolution must not be the last syllable of a polysyllabic word. Moreover, the syllables in resolution most often form part of the same word as the following short or anceps, e.g.: Ion 1143.

As described by the ancient metricians, catalexis is a matter of arithmetic rather than rhythm. They develop the idea in their usual way, mechanically and mathematically, adding and subtracting elements, so as to produce ‘brachycatalexis’ and ‘hypercatalexis’. These are now mere metrical-glossary terms, but in catalexismodern metricians have seen a genuine relationship between cola and a rhythmic effect more or less comprehensible even to us. Wilamowitz, T.D. Goodell, and A.M. Dale explore the concept to some extent, but current hand books (...) and general treatises give it only perfunctory and superficial treatment, while casual appearances of the term offer the reader glimpses of a theoretical substructure which hasnot been explicitly and coherently explained. (shrink)

A fundamental problem in the construction of local electromagnetic interactions in the framework of relativistic wave equations of Klein-Gordon or Dirac type is discussed, and shown to be resolved in a relativistic quantum theory of events described by functions in a Hilbert space on the manifold of space-time. The relation, abstracted from the structure of the electromagnetic current, between sequences of events, parametrized by an evolution parameter τ (“historical time”), and the commonly accepted notion of particles is reviewed. As an (...) illustration of these ideas, a perturbative calculation is made for photon emission from a charged two-body system in which the electromagnetic field is quantized in the usual way. The result is in essential agreement with calculations in which the charged particles are treated in the framework of nonrelativistic quantum mechanics, and provides them with a relativistic interpretation. In particular, we obtain a relativistically invariant form of the Bohr radiation condition. (shrink)

Paul Maas extended the law still further: ‘The following rule applies to several metres which contain the rhythm : no word can end after a long anceps, except at the caesura in the middle of the line.’ He lists the types of metre to which the rule applies as the stichic iambic trimeters and trochaic tetrameters of the early iambographers and the Attic tragedians, the dactylo-epitrites of Bacchylides, the trochaic trimeters and dimeters of Alcman's Partheneion, the end of the iambic (...) tetrameters of Sophocles' Ichneutae, and ‘certain rare metres, whose conformity to this rule may be due to accident’. (shrink)

The National Blood Policy in India relies heavily on voluntary blood donors, as they are usually assumed to be associated with low levels of transfusion-transmitted infections . In India, it is mandatory to test every unit of blood collected for hepatitis B, hepatitis C, HIV/AIDS, syphilis and malaria. Donors come to the blood bank with altruistic intentions. If donors test positive to any of the five infections, their blood is discarded. Although the blood policy advocates disclosure of TTI status, donors (...) are not, in practice, informed about their results. The onus is on the donor to contact the blood bank. Out of approximately 16 000 donations in the past 2 years, 438 tested positive for TTI, including 107 for HIV. Only 20% of the donors contacted the blood bank; none of them were HIV positive. Disclosure by blood banks of TTI status by telephone or mail has resulted in serious consequences for some donors. Health providers face an ethical dilemma, in the absence of proper mechanisms in place for disclosure of test results, regarding notification to donors who may test positive but remain ignorant of their TTI status. Given the high cost of neglecting to notify infected donors, the authors strongly recommend the use of rapid tests before collecting blood, instead of the current practice, which takes 3 h to obtain results, and disclosure of results directly to the donor by a counsellor, to avoid dropouts and to ensure confidentiality. (shrink)

As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to (...) test vaccines in wild populations of apes: i) protect apes; ii) reduce Ebola transmission from wild animals to humans; and iii) accelerate vaccine development and licensing for humans. Data obtained from studies of vaccines among wild apes and chimpanzees may even be considered sufficient for licensing new vaccines for humans. This strategy will serve to benefit both wild apes and humans. (shrink)

This is a new release of the original 1924 edition.

This case study aims to preserve and disseminate cultural heritage information about the North American community folk dance tradition of contra dance through development of a thesaurus of choreographic terms and a domain ontology. A survey of dance resources was conducted, reviewing historic and modern examples of contra dance choreography notation and instructions, records of dance events, and recordings of dance performances. Domain and content analysis were performed on the resources to collect and organize concepts and themes regarding choreographic components (...) and their relationships, the structure and function of cultural works, their creative expressions, and the evidence of those expressions in documents and recordings. Vocabulary used in the description of contra dance choreography was identified, classified, and notated to build a thesaurus, which was used as the basis of a domain ontology. Ontology building methodology and existing conceptual models for cultural heritage domains guided the ontology development and revision phases. The study also seeks to safeguard an intangible cultural heritage by applying knowledge organization and semantic approaches to folk dance in order to model such challenges as multiple, simultaneous modes of communication and forms of representation, modular conceptual components, descriptive sequences, differing levels of structured information, and complex cultural networks found at various levels of domain discourse. (shrink)

Gilbert Ryle in The Concept of Mind pronounced the “official doctrine” regarding the nature of the mind and the body as “hailing chiefly from Descartes.” That doctrine, anathematized by Ryle as “the dogma of the ghost in the machine,” is said to hold that every human being is composed of a body and a mind, that the body is physical whereas the mind is not, and that the mind may continue to exist when the body is destroyed. Ryle’s famous attack (...) on the official doctrine has undoubtedly stimulated Cartesian studies, both in those who wish to understand Descartes better in order to make the defense of the doctrine more effective and in those who wish to attack it, sometimes even with arguments which Ryle himself would have rejected. Occasionally, one reads a reference to “Platonic dualism,” not so much as a clearly defined alternative to Cartesian dualism but rather as an inchoate or loose version of Descartes’ doctrine. A recent exception is Richard Rorty who in the first chapter of his book Philosophy and the Mirror of Nature has insisted on the difference between the Platonic and the Cartesian positions, although it should perhaps be added that his hostility to the former is if anything greater than his hostility to the latter. Without suggesting that there are not obvious similarities in the Platonic and Cartesian versions of dualism, it will perhaps be useful to try to penetrate beneath the slogans in order to get a clearer picture of the arguments which impelled Plato to hold a position the strangeness which was evident even to his contemporaries. (shrink)

Open peer commentary on the article “Negotiating Between Learner and Mathematics: A Conceptual Framework to Analyze Teacher Sensitivity Toward Constructivism in a Mathematics Classroom” by Philip Borg, Dave Hewitt & Ian Jones. Upshot: My commentary has two general goals. First, I investigate how basic principles of radical constructivism might be used in constructing models of mathematics teaching. Toward that end, I found that I was not in complete intersubjective agreement with Borg et al.’s use of some basic terms. Second, I (...) explore what mathematics teaching might look like in what is construed as constructivist mathematics teaching. Toward that end, I comment on Borg et al.’s use of “negotiation” and explain how a constructivist teacher can establish experiential models of students’ mathematics. (shrink)

The level of medical care to patients and the success of the implementation of the national project "Health" depend on the health status and doctor's professionalism. Modern healthcare reform is being implemented by optimizing costs, merging medical organizations, closing ineffective hospitals, expanding the use of high-tech care and informatization of the doctor's activities. All this makes it necessary to assess the health of doctors. Scientists have studied the quality of life and identified the professional burnout of doctors in children's clinics (...) in different age groups. Primary care pediatricians have a higher quality of life score when compared to the standard [1]. However, all groups have a high level of professional burnout. The pre-retirement group of doctors has more unfavorable profile. They are highly professional specialists but may experience emotional discomfort because the pension system has been reformed. This situation requires the introduction of preventive work with doctors of this age as a group with great potential and capable of professional longevity. (shrink)

Open peer commentary on the article “Religion: A Radical-Constructivist Perspective” by Andreas Quale. Upshot: The first of my three main goals in this commentary is to demonstrate that Quale’s radical separation between cognitive and non-cognitive knowledge is not viable. The second is to establish Quale’s assertion that a radical constructivist cannot be genuinely religious is a result of taking radical constructivism and religion as abstracted first-order models and is a result of comparing and contrasting elements of these models. The third (...) goal is to establish how religious radical constructivists establish relations between their religious beliefs and their radical constructivist beliefs. To accomplish the first goal, I appeal to the work of Damasio to establish that what Quale refers to as “non-cognitive knowledge” is inextricably cognitive. I also appeal to the work of both Damasio and von Glasersfeld to demonstrate that the Cartesian duality between mind and body is not viable. To accomplish the last two goals, I make a distinction between first- and second-order knowledge and contrast Quale’s argument that a radical constructivist cannot be religious with the relation between religious beliefs and radical constructivism from the perspective of actual religious radical constructivists. (shrink)

The elements which every schoolboy learns on beginning Latin Verse Composition include a number of rules which seem arbitrarily designed to make the game harder. In hexameters, he is told, he must have a masculine caesura either in the third foot or in the second and fourth, and end normally with a disyllabic or a trisyllable; in pentameters he must end with a disyllabic; and in neither line may a single monosyllable stand at the end. Rarely, in my experience, is (...) any reason given him by way of redress, and he will search for one in vain in most of the school text-books, in introductions like Postgate's to Tibullus and Propertius, and in histories of Latin literature like Wight Duff's and Mackail's. This reticence may be due to the dissensions of experts on this subject and on the subject of Latin accentuation in general, but the theory that predominates in England, among those who hold a theory at all, explains so many of the phenomena that it deserves to be more widely and precisely known. The most detailed exposition of it is by E. H. Sturtevant, who summed up his analyses in a pair of articles in the Transactions of the American Philological Association in 1923–4. While his careful work is invaluable as marshalling the statistics and evidence, it errs on the side of excessive minuteness, and leaves room not merely for some additions, but for a different kind of treatment concerned less with bare statistics and more with poetic principles and historical development. Since Latin Verse Composition plays such an important part in English higher classical education, it seems desirable that a less technical and more accessible account should be available for English readers. Such an account I attempt to give here, keeping separate as far as possible the exposition and the consideration of the criticisms and rival theories that have been advanced. (shrink)

В книге на материале различных культурных ареалов (Западной Европы, Руси / России, цивилизации Востока) и эпох (Античности, Средневековья, Нового времени) исследуются образы времени, коллективные представления о связи времен, о прошлом и будущем.